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 B  AB  JB*  OB  OE*  OE
 S  AS  JS*  OS  OS*  3
 JB
 JS
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Detailed Insider History for:
IONIS PHARMACEUTICALS INC: IONS
Price: 12/12/25 52-Wk
High		 52-Wk
Low		 Mkt Cap (mm) Shrs Out (mm) 3-Mth Ave
Vol (m)		 Ind. Yield Short Int
% Float		 Inst. Owned Insider Owned
$80.82 $83.61 $23.95 $13,091 162 2,443 0.0% 12.7% 106.57% 0.62%
Exch Sector Industry Sub-Industry
NasdaqGS Manufacturing Chemicals And Allied Products Pharmaceutical Preparations
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Insider Statistics
T N H M S
Filer Name
Insider Title
Trans Type
Dollar Value
Shares Traded
Trans Date From
Trans Date To
Trans Price From
Trans Price To
Total Holdings
Delta % Owned
Owned
Other Info
Input Date
1
1y
2
50%
3%
1
WENDER JOSEPH H
DIR
AS
$2,262,848
28,000
---
12/1/25
$80.67
$81.23
36,035
-43.7
I
10b
12/3/25 - 7:01:07 pm
2
1y
25
72%
-33%
8
KLEIN JOSEPH III
DIR
AS
$960,000
12,000
---
11/25/25
---
$80.00
---
All
I
10b
11/28/25 - 5:51:58 pm
3
    
 
KLEIN JOSEPH III
DIR
JB
---
12,000
---
11/25/25
---
---
4,000
---
I
10b
11/28/25 - 5:51:58 pm
4
    
 
DEVERS SHANNON L
VP,HR
OS
$1,357,442
16,777
---
11/25/25
---
$80.91
17,494
-49.0
D
10b
11/28/25 - 5:51:52 pm
5
    
 
DEVERS SHANNON L
VP,HR
OE
$902,099
16,777
---
11/25/25
---
$53.77
34,271
95.9
D
10b
11/28/25 - 5:51:52 pm
6
1w
1
0%
11%
4
HERMAN JOAN E
DIR
OS
$3,173,830
44,000
---
11/19/25
---
$72.13
46,086
-48.8
D
---
11/20/25 - 5:12:11 pm
7
    
 
HERMAN JOAN E
DIR
OE
$2,525,400
44,000
---
11/19/25
$40.05
$63.90
78,086
129.1
D
---
11/20/25 - 5:12:11 pm
8
1y
4
50%
-23%
1
WENDER JOSEPH H
DIR
OB
$390,720
16,000
---
11/18/25
---
$24.42
16,000
New
D
---
11/20/25 - 5:12:23 pm
9
    
 
BIRCHLER BRIAN
VP,OO
AS
$609,379
8,000
---
11/6/25
---
$76.17
48,826
-14.1
D
10b
11/7/25 - 5:13:09 pm
10
1y
24
92%
-69%
1
GEARY RICHARD S
VP
OS
$2,621,816
34,639
11/5/25
11/6/25
$75.01
$75.42
59,657
-36.7
D
10b
11/7/25 - 5:12:44 pm
11
    
 
GEARY RICHARD S
VP
OE
$2,045,308
34,639
11/5/25
11/6/25
$56.78
$60.89
77,957
80.0
D
10b
11/7/25 - 5:12:44 pm
12
1y
24
92%
-69%
1
GEARY RICHARD S
VP
AS
$126,091
1,680
---
11/3/25
---
$75.05
59,657
-2.7
D
A,10b
11/7/25 - 5:12:38 pm
13
    
 
GEARY RICHARD S
VP
OE
$98,576
1,680
---
11/3/25
---
$56.78
60,562
2.9
D
A,10b
11/7/25 - 5:12:38 pm
14
1y
24
92%
-69%
1
GEARY RICHARD S
VP
OS
$6,829,432
90,929
10/31/25
11/3/25
---
$75.05
59,657
-60.4
D
10b
11/3/25 - 8:14:45 pm
15
    
 
GEARY RICHARD S
VP
OE
$4,173,213
70,929
10/31/25
11/3/25
$56.78
$60.89
114,321
163.5
D
10b
11/3/25 - 8:14:45 pm
16
1y
2
50%
3%
1
WENDER JOSEPH H
DIR
AS
$2,072,578
28,000
10/30/25
10/31/25
$72.19
$75.16
64,035
-30.4
I
10b
11/3/25 - 8:14:56 pm
17
1y
1
0%
92%
2
LOSCALZO JOSEPH
DIR
OS
$1,201,669
16,000
---
10/31/25
---
$75.10
36,330
-30.6
D
10b
11/3/25 - 8:14:50 pm
18
    
 
LOSCALZO JOSEPH
DIR
OE
$835,520
16,000
---
10/31/25
---
$52.22
52,330
44.0
D
10b
11/3/25 - 8:14:50 pm
19
    
 
SWAYZE ERIC
VP
S
$3,902
53
---
10/16/25
---
$73.62
256
-17.2
I
R
10/16/25 - 8:16:46 pm
20
    
 
DEVERS SHANNON L
VP,HR
OS
$530,638
7,263
10/15/25
10/16/25
$72.94
$73.62
15,937
-31.3
D
R,10b
10/16/25 - 8:16:08 pm
21
    
 
SWAYZE ERIC
VP
JB
---
125
---
10/15/25
---
---
309
67.9
I
R
10/16/25 - 8:16:46 pm
22
1y
23
70%
-34%
3
PARSHALL B LYNNE
DIR
AS
$358,722
5,000
---
10/15/25
---
$71.74
61,344
-7.5
D
10b
10/16/25 - 8:16:14 pm
23
    
 
DEVERS SHANNON L
VP,HR
JB
---
2,820
---
10/15/25
---
---
18,757
17.7
D
R,10b
10/16/25 - 8:16:08 pm
24
    
 
DEVERS SHANNON L
VP,HR
OE
$291,060
6,000
---
10/15/25
---
$48.51
21,937
37.6
D
R,10b
10/16/25 - 8:16:08 pm
25
    
 
BIRCHLER BRIAN
VP,OO
OS
$1,723,987
23,900
10/14/25
10/15/25
$72.03
$72.23
56,826
-29.6
D
10b
10/16/25 - 8:15:51 pm
26
    
 
BIRCHLER BRIAN
VP,OO
OE
$1,285,103
23,900
10/14/25
10/15/25
---
$53.77
69,251
52.7
D
10b
10/16/25 - 8:15:51 pm
27
    
 
SWAYZE ERIC
VP
AS
$472,718
6,849
---
10/6/25
---
$69.02
30,453
-18.4
D
10b
10/8/25 - 6:37:06 pm
28
1y
38
84%
-62%
1
O NEIL PATRICK R
VP,LO,GC
OS
$937,338
13,441
---
10/6/25
---
$69.27
53,889
-20.0
D
10b
10/8/25 - 6:37:00 pm
29
    
 
O NEIL PATRICK R
VP,LO,GC
OE
$539,274
10,200
---
10/6/25
---
$52.87
67,330
17.9
D
10b
10/8/25 - 6:37:00 pm
30
1y
33
73%
-37%
1
MONIA BRETT P
CEO,DIR
AS
$30,268
437
---
10/6/25
---
$69.26
179,572
-0.2
D
10b
10/8/25 - 6:36:54 pm
31
    
 
BAROLDI JOSEPH
VP
AS
$112,725
1,625
---
10/6/25
---
$69.37
30,301
-5.1
D
10b
10/8/25 - 6:36:47 pm
32
    
 
SWAYZE ERIC
VP
OS
$1,793,744
27,114
10/1/25
10/2/25
$66.09
$66.23
37,302
-42.1
D
10b
10/2/25 - 7:36:11 pm
33
    
 
SWAYZE ERIC
VP
OE
$1,457,920
27,114
10/1/25
10/2/25
---
$53.77
51,444
111.4
D
10b
10/2/25 - 7:36:11 pm
34
1y
38
84%
-62%
1
O NEIL PATRICK R
VP,LO,GC
OS
$4,377,055
64,664
---
10/2/25
---
$67.69
57,130
-53.1
D
10b
10/2/25 - 7:35:57 pm
35
    
 
O NEIL PATRICK R
VP,LO,GC
OE
$3,813,257
64,664
---
10/2/25
$56.78
$60.89
91,591
240.1
D
10b
10/2/25 - 7:35:57 pm
36
    
 
BAROLDI JOSEPH
VP
OS
$1,020,210
15,000
---
10/2/25
---
$68.01
31,926
-32.0
D
10b
10/2/25 - 7:35:51 pm
37
    
 
BAROLDI JOSEPH
VP
OE
$477,000
15,000
---
10/2/25
---
$31.80
46,926
47.0
D
10b
10/2/25 - 7:35:51 pm
38
1y
2
50%
3%
1
WENDER JOSEPH H
DIR
AS
$1,100,385
16,800
---
10/1/25
---
$65.50
92,035
-15.4
I
10b
10/2/25 - 7:36:16 pm
39
1y
38
84%
-62%
1
O NEIL PATRICK R
VP,LO,GC
OS
$1,634,922
25,300
9/29/25
9/30/25
$64.54
$64.68
57,130
-30.7
D
10b
10/1/25 - 4:55:36 pm
40
    
 
O NEIL PATRICK R
VP,LO,GC
OE
$1,436,534
25,300
9/29/25
9/30/25
---
$56.78
71,957
54.2
D
10b
10/1/25 - 4:55:36 pm
41
1y
24
92%
-69%
1
GEARY RICHARD S
VP
OS
$3,777,668
57,900
---
9/30/25
---
$65.24
79,657
-42.1
D
10b
10/1/25 - 4:55:29 pm
42
    
 
GEARY RICHARD S
VP
OE
$3,113,283
57,900
---
9/30/25
---
$53.77
137,557
72.7
D
10b
10/1/25 - 4:55:29 pm
43
1y
22
73%
-51%
1
HOUGEN ELIZABETH L
VP,CFO
OS
$3,249,734
49,800
---
9/30/25
---
$65.26
110,500
-31.1
D
10b
10/1/25 - 4:55:20 pm
44
    
 
HOUGEN ELIZABETH L
VP,CFO
OE
$2,677,746
49,800
---
9/30/25
---
$53.77
160,300
45.1
D
10b
10/1/25 - 4:55:20 pm
45
1y
38
84%
-62%
1
O NEIL PATRICK R
VP,LO,GC
OS
$109,787
1,700
---
9/12/25
---
$64.58
57,130
-2.9
D
10b
9/16/25 - 4:56:38 pm
46
    
 
O NEIL PATRICK R
VP,LO,GC
OE
$96,526
1,700
---
9/12/25
---
$56.78
58,830
3.0
D
10b
9/16/25 - 4:56:38 pm
47
    
 
BAROLDI JOSEPH
VP
OS
$742,838
11,950
---
9/9/25
---
$62.16
31,926
-27.2
D
10b
9/11/25 - 5:05:07 pm
48
    
 
BAROLDI JOSEPH
VP
OE
$380,010
11,950
---
9/9/25
---
$31.80
43,876
37.4
D
10b
9/11/25 - 5:05:07 pm
49
1y
38
84%
-62%
1
O NEIL PATRICK R
VP,LO,GC
OS
$1,355,661
21,000
---
9/9/25
---
$64.56
57,130
-26.9
D
10b
9/11/25 - 5:04:46 pm
50
    
 
O NEIL PATRICK R
VP,LO,GC
OE
$1,274,580
21,000
---
9/9/25
---
$56.78
77,130
37.4
D
10b
9/11/25 - 5:04:46 pm
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