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 S  AS  JS*  OS  OS*  3
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 JS
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Detailed Insider History for:
DENALI THERAPEUTICS INC: DNLI
Price: 10/24/25 52-Wk
High		 52-Wk
Low		 Mkt Cap (mm) Shrs Out (mm) 3-Mth Ave
Vol (m)		 Ind. Yield Short Int
% Float		 Inst. Owned Insider Owned
$15.96 $33.33 $10.57 $2,334 146 1,964 0.0% 11.1% 99.52% 9.83%
Exch Sector Industry Sub-Industry
NasdaqGS Manufacturing Chemicals And Allied Products Biological Products, (No Disgnostic Substances)
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Insider Statistics
T N H M S
Filer Name
Insider Title
Trans Type
Dollar Value
Shares Traded
Trans Date From
Trans Date To
Trans Price From
Trans Price To
Total Holdings
Delta % Owned
Owned
Other Info
Input Date
1
    
 
WATTS RYAN J
PR,CEO,DIR
JS
---
50,000
---
9/3/25
---
---
2,152,604
-2.3
I
---
9/5/25 - 4:43:51 pm
2
1y
51
69%
-4%
1
HO CAROLE
O
AS
$51,684
3,743
8/12/25
8/13/25
$13.58
$14.64
216,585
-1.7
D
R,10b
8/14/25 - 8:33:05 pm
3
1y
46
70%
6%
1
SCHUTH ALEXANDER O
SEC
S
$39,884
2,937
---
8/12/25
---
$13.58
242,346
-1.2
D
R
8/14/25 - 8:33:49 pm
4
1y
1
0%
-20%
1
HO CAROLE
O
OB
$30,365
44,655
---
8/5/25
---
$0.68
220,328
25.4
D
---
8/7/25 - 5:34:32 pm
5
1y
46
76%
-3%
1
WATTS RYAN J
PR,CEO,DIR
OS
$7,429,230
495,282
---
7/9/25
---
$15.00
253,071
-66.2
D
10b
7/11/25 - 5:13:23 pm
6
    
 
WATTS RYAN J
PR,CEO,DIR
OE
$520,792
495,282
---
7/9/25
$0.68
$5.28
748,353
195.7
D
10b
7/11/25 - 5:13:23 pm
7
    
 
BAKER BROS ADVISORS LP
DIR
JB
---
21,130
---
6/3/25
---
---
3,415,958
0.6
I
R
6/5/25 - 5:02:52 pm
8
    
 
BAKER BROS ADVISORS LP
DIR
3
---
---
---
6/3/25
---
---
326,302
---
I
---
6/5/25 - 4:57:49 pm
9
    
 
BAKER BROS ADVISORS LP
DIR
3
---
---
---
6/3/25
---
---
3,405,393
---
I
---
6/5/25 - 4:57:49 pm
10
    
 
BAKER JULIAN
DIR
3
---
---
---
6/3/25
---
---
---
---
---
---
6/5/25 - 4:53:31 pm
11
    
 
COOK JENNIFER E
DIR
JB
---
6,037
---
6/3/25
---
---
26,075
30.1
D
R
6/5/25 - 4:34:17 pm
12
    
 
FLATLEY JAY T
DIR
JB
---
6,037
---
6/3/25
---
---
16,220
59.3
D
R
6/5/25 - 4:33:18 pm
13
    
 
KLEIN PETER S
DIR
JB
---
6,037
---
6/3/25
---
---
27,533
28.1
D
R
6/5/25 - 4:31:24 pm
14
    
 
KROGNES STEVE E
DIR
JB
---
6,037
---
6/3/25
---
---
31,794
23.4
D
R
6/5/25 - 4:29:16 pm
15
    
 
SCHENKEIN DAVID P
DIR
JB
---
6,037
---
6/3/25
---
---
15,257
65.5
D
R
6/5/25 - 4:26:51 pm
16
    
 
THORNBERRY NANCY
DIR
JB
---
6,037
---
6/3/25
---
---
24,717
32.3
D
R
6/5/25 - 4:25:53 pm
17
    
 
TESSIER LAVIGNE MARC
DIR
JB
---
6,037
---
6/3/25
---
---
1,886,576
0.3
D
R
6/5/25 - 4:23:08 pm
18
1y
51
69%
-4%
1
HO CAROLE
O
S
$308,291
15,162
1/6/25
1/7/25
$20.22
$20.81
175,673
-7.9
D
R
1/8/25 - 8:26:37 pm
19
1y
46
70%
6%
1
SCHUTH ALEXANDER O
SEC
S
$308,291
15,162
1/6/25
1/7/25
$20.22
$20.81
244,308
-5.8
D
R
1/8/25 - 8:25:44 pm
20
1y
46
76%
-3%
1
WATTS RYAN J
PR,CEO,DIR
S
$750,955
36,916
1/6/25
1/7/25
$20.22
$20.81
253,071
-12.7
D
R
1/8/25 - 8:24:43 pm
21
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
S
$69,485
3,339
---
1/7/25
---
$20.81
25,757
-11.5
D
R
1/8/25 - 8:23:57 pm
22
    
 
WATTS RYAN J
PR,CEO,DIR
JB
---
54,180
---
1/3/25
---
---
289,987
23.0
D
R
1/7/25 - 6:59:45 pm
23
    
 
SCHUTH ALEXANDER O
SEC
JB
---
54,180
---
1/3/25
---
---
259,470
26.4
D
R
1/7/25 - 6:57:55 pm
24
    
 
HO CAROLE
O
JB
---
54,180
---
1/3/25
---
---
190,835
39.6
D
R
1/7/25 - 6:56:19 pm
25
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$64,403
3,080
---
1/2/25
---
$20.91
107,976
-2.8
D
10b
1/3/25 - 4:13:51 pm
26
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
AS
$607,500
30,000
---
12/31/24
---
$20.25
29,096
-50.8
D
10b
1/3/25 - 4:14:23 pm
27
1y
7
43%
5%
1
SCHUTH ALEXANDER O
SEC
OB
$35,418
6,708
---
12/27/24
---
$5.28
205,290
3.4
D
---
12/31/24 - 4:18:12 pm
28
1y
1
0%
-20%
1
HO CAROLE
O
OB
$12,135
17,845
---
11/25/24
---
$0.68
136,655
15.0
D
---
11/27/24 - 4:44:42 pm
29
1y
7
43%
5%
1
SCHUTH ALEXANDER O
SEC
OB
$13,951
20,516
---
11/22/24
---
$0.68
198,582
11.5
D
---
11/26/24 - 5:19:27 pm
30
1y
5
80%
-28%
3
SCHENKEIN DAVID P
DIR
OS
$1,932,665
59,441
---
11/11/24
$32.09
$32.87
9,220
-86.6
D
10b
11/13/24 - 4:18:59 pm
31
    
 
SCHENKEIN DAVID P
DIR
OE
$848,970
47,165
---
11/11/24
---
$18.00
68,661
219.4
D
10b
11/13/24 - 4:18:59 pm
32
1y
46
70%
6%
1
SCHUTH ALEXANDER O
SEC
OS
$465,286
15,558
---
11/7/24
$29.68
$31.29
178,066
-8.0
D
10b
11/12/24 - 4:44:51 pm
33
    
 
SCHUTH ALEXANDER O
SEC
OE
$82,146
15,558
---
11/7/24
---
$5.28
193,624
8.7
D
10b
11/12/24 - 4:44:51 pm
34
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$30,600
1,020
---
11/7/24
---
$30.00
111,056
-0.9
D
10b
11/12/24 - 4:43:29 pm
35
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$83,376
3,080
---
11/1/24
---
$27.07
112,076
-2.7
D
10b
11/5/24 - 4:21:27 pm
36
1y
46
76%
-3%
1
WATTS RYAN J
PR,CEO,DIR
OS
$1,107,600
40,000
---
10/18/24
---
$27.69
235,807
-14.5
D
10b
10/22/24 - 4:30:57 pm
37
    
 
WATTS RYAN J
PR,CEO,DIR
OE
$27,200
40,000
---
10/18/24
---
$0.68
275,807
17.0
D
10b
10/22/24 - 4:30:57 pm
38
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
AS
$870,900
30,000
---
9/30/24
---
$29.03
29,096
-50.8
D
10b
10/2/24 - 4:37:42 pm
39
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$30,600
1,020
---
9/13/24
---
$30.00
115,156
-0.9
D
10b
9/16/24 - 4:17:52 pm
40
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$77,007
3,080
---
9/3/24
$24.99
$25.37
116,176
-2.6
D
10b
9/4/24 - 6:26:22 pm
41
1y
46
70%
6%
1
SCHUTH ALEXANDER O
SEC
AS
$200,401
8,353
8/20/24
8/21/24
$23.54
$24.78
178,066
-4.5
D
R,10b
8/22/24 - 4:14:40 pm
42
1y
51
69%
-4%
1
HO CAROLE
O
AS
$549,928
22,458
8/20/24
8/21/24
$23.79
$24.96
118,810
-15.9
D
R,10b
8/22/24 - 4:14:08 pm
43
1y
46
76%
-3%
1
WATTS RYAN J
PR,CEO,DIR
S
$53,765
2,260
---
8/20/24
---
$23.79
235,807
-0.9
D
R
8/22/24 - 4:16:23 pm
44
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
S
$41,085
1,727
---
8/20/24
---
$23.79
32,677
-5.0
D
R
8/22/24 - 4:15:47 pm
45
1y
46
70%
6%
1
SCHUTH ALEXANDER O
SEC
S
$52,006
2,272
---
8/13/24
---
$22.89
186,419
-1.2
D
R
8/15/24 - 4:10:01 pm
46
1y
51
69%
-4%
1
HO CAROLE
O
S
$53,494
2,337
---
8/13/24
---
$22.89
141,268
-1.6
D
R
8/15/24 - 4:09:18 pm
47
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
AS
$663,668
30,000
---
7/1/24
$22.12
$22.80
34,404
-46.6
D
10b
7/3/24 - 9:13:45 pm
48
1y
24
75%
-21%
4
SATO VICKI L
DIR
AS
$68,204
3,080
---
7/1/24
$22.12
$22.86
119,256
-2.5
D
10b
7/3/24 - 9:13:04 pm
49
1y
22
82%
-17%
1
KROGNES STEVE E
DIR
AS
$14,992
688
---
6/13/24
---
$21.79
52,620
-1.3
D
10b
7/3/24 - 9:13:45 pm
50
    
 
COOK JENNIFER E
DIR
AS
$31,682
1,458
---
6/6/24
---
$21.73
20,038
-6.8
D
10b
6/10/24 - 8:06:11 pm
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