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 has been a registered insider since 2003.
                                      
                                  As Chief Executive Officer at Denali Therapeutics,  last made a transaction on 7/9/2025.
                              
| 
                              InsiderInsights.com Purchase Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 1 | 0% | -16% | -- | -- | 1 Year | 1 | 0% | -- | -- | -- | 
| 1 | 0% | -9% | -- | -- | 9 Month | 1 | 0% | -- | -- | -- | 
| 1 | 100% | 9% | -- | -- | 6 Month | 1 | 0% | -- | -- | -- | 
| 1 | 0% | -34% | -- | -- | 3 Month | 1 | 0% | -- | -- | -- | 
| 1 | 0% | -13% | -- | -- | 1 Month | 1 | 0% | -- | -- | -- | 
| 1 | 0% | -7% | -- | -- | 1 Week | 1 | 0% | -- | -- | -- | 
| 
                              InsiderInsights.com Sales Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 46 | 76% | -3% | -28% | 362 | 1 Year | 46 | 0% | -- | -- | -- | 
| 47 | 81% | -5% | -24% | 490 | 9 Month | 47 | 0% | -- | -- | -- | 
| 47 | 62% | -7% | -10% | 174 | 6 Month | 47 | 0% | -- | -- | -- | 
| 48 | 65% | -6% | -9% | 97 | 3 Month | 48 | 0% | -- | -- | -- | 
| 48 | 52% | -1% | -2% | 59 | 1 Month | 48 | 0% | -- | -- | -- | 
| 48 | 46% | -1% | 1% | 36 | 1 Week | 48 | 0% | -- | -- | -- | 
| Scorecards Updated 10/30/2025 12:27 PM EST | Latest Transaction Date: | 7/9/2025 | 
| Average days between Transaction and Entered Dates: | 3 |