Middleton Fred A has been a registered insider at 6 firms since 2004.
                                      
                                  As a Beneficial Owner of 5% or more of a class of the company's shares at GRAYBUG VISION, INC., Middleton Fred A last made a transaction on 12/6/2024.
                              
                                 As a Director at Chimerix Inc, Middleton Fred A last made a transaction on 11/17/2023.
                              
                                 As a Director at Stereotaxis, Inc., Middleton Fred A last made a transaction on 3/2/2018.
                              
                                 As a Director at Endocyte,; Inc. , Middleton Fred A last made a transaction on 1/19/2016.
                              
                                 As a Director at Pacira Pharmaceuticals,; Inc. , Middleton Fred A last made a transaction on 6/24/2013.
                              Middleton Fred A has also been considered an insider at 1 other firms since 2004. 
                              
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                              InsiderInsights.com Purchase Scorecard
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|  |  | 
                              Transaction Date
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| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 3 | 0% | -26% | -15% | 31 | 1 Year | 3 | 0% | -- | -- | -- | 
| 4 | 25% | -10% | -15% | 26 | 9 Month | 4 | 0% | -- | -- | -- | 
| 4 | 0% | -38% | -41% | 20 | 6 Month | 4 | 0% | -- | -- | -- | 
| 4 | 25% | -18% | -25% | 32 | 3 Month | 4 | 0% | -- | -- | -- | 
| 4 | 25% | -8% | -14% | 28 | 1 Month | 4 | 0% | -- | -- | -- | 
| 4 | 25% | 4% | -1% | 26 | 1 Week | 4 | 0% | -- | -- | -- | 
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                              InsiderInsights.com Sales Scorecard
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|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| -- | -- | -- | -- | -- | 1 Year | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 9 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 6 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 3 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Week | -- | -- | -- | -- | -- | 
| Scorecards Updated 10/31/2025 10:09 AM EST | Latest Transaction Date: | 12/6/2024 | 
| Average days between Transaction and Entered Dates: | 3 | 
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                              InsiderInsights.com Purchase Scorecard
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|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 10 | 40% | 52% | -10% | 701 | 1 Year | 10 | 0% | -- | -- | -- | 
| 10 | 30% | 14% | -16% | 309 | 9 Month | 10 | 0% | -- | -- | -- | 
| 10 | 40% | 5% | -4% | 133 | 6 Month | 10 | 0% | -- | -- | -- | 
| 10 | 40% | 12% | -1% | 132 | 3 Month | 10 | 0% | -- | -- | -- | 
| 10 | 30% | -4% | -3% | 43 | 1 Month | 10 | 0% | -- | -- | -- | 
| 10 | 40% | -1% | -3% | 26 | 1 Week | 10 | 0% | -- | -- | -- | 
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                              InsiderInsights.com Sales Scorecard
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|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| -- | -- | -- | -- | -- | 1 Year | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 9 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 6 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 3 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Week | -- | -- | -- | -- | -- | 
| Scorecards Updated 10/31/2025 10:09 AM EST | Latest Transaction Date: | 11/17/2023 | 
| Average days between Transaction and Entered Dates: | 3 | 
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                              InsiderInsights.com Purchase Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 4 | 50% | 71% | 71% | 195 | 1 Year | 4 | 0% | -- | -- | -- | 
| 4 | 50% | 67% | 44% | 190 | 9 Month | 4 | 0% | -- | -- | -- | 
| 4 | 100% | 35% | 30% | 32 | 6 Month | 4 | 0% | -- | -- | -- | 
| 4 | 50% | 22% | 2% | 92 | 3 Month | 4 | 0% | -- | -- | -- | 
| 4 | 25% | 22% | -16% | 162 | 1 Month | 4 | 0% | -- | -- | -- | 
| 4 | 50% | -0% | -3% | 37 | 1 Week | 4 | 0% | -- | -- | -- | 
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                              InsiderInsights.com Sales Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 6 | 100% | -35% | -33% | 29 | 1 Year | 6 | 0% | -- | -- | -- | 
| 6 | 100% | -37% | -36% | 57 | 9 Month | 6 | 0% | -- | -- | -- | 
| 6 | 67% | -24% | -38% | 57 | 6 Month | 6 | 0% | -- | -- | -- | 
| 6 | 67% | -3% | -24% | 94 | 3 Month | 6 | 0% | -- | -- | -- | 
| 6 | 83% | -5% | -5% | 22 | 1 Month | 6 | 0% | -- | -- | -- | 
| 6 | 67% | -3% | -3% | 18 | 1 Week | 6 | 0% | -- | -- | -- | 
| Scorecards Updated 10/31/2025 10:09 AM EST | Latest Transaction Date: | 3/2/2018 | 
| Average days between Transaction and Entered Dates: | 2 | 
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                              InsiderInsights.com Purchase Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 5 | 60% | 100% | 172% | 262 | 1 Year | 5 | 0% | -- | -- | -- | 
| 5 | 80% | 140% | 221% | 243 | 9 Month | 5 | 0% | -- | -- | -- | 
| 5 | 100% | 91% | 118% | 129 | 6 Month | 5 | 0% | -- | -- | -- | 
| 5 | 100% | 57% | 61% | 30 | 3 Month | 5 | 0% | -- | -- | -- | 
| 5 | 100% | 8% | 10% | 12 | 1 Month | 5 | 0% | -- | -- | -- | 
| 5 | 100% | 7% | 9% | 11 | 1 Week | 5 | 0% | -- | -- | -- | 
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                              InsiderInsights.com Sales Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| -- | -- | -- | -- | -- | 1 Year | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 9 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 6 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 3 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Week | -- | -- | -- | -- | -- | 
| Scorecards Updated 10/31/2025 10:09 AM EST | Latest Transaction Date: | 1/19/2016 | 
| Average days between Transaction and Entered Dates: | 2 | 
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                              InsiderInsights.com Purchase Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 3 | 100% | 76% | 55% | 64 | 1 Year | 3 | 0% | -- | -- | -- | 
| 3 | 100% | 49% | 9% | 121 | 9 Month | 3 | 0% | -- | -- | -- | 
| 3 | 100% | 39% | 36% | 9 | 6 Month | 3 | 0% | -- | -- | -- | 
| 3 | 100% | 53% | 60% | 20 | 3 Month | 3 | 0% | -- | -- | -- | 
| 3 | 100% | 7% | 3% | 11 | 1 Month | 3 | 0% | -- | -- | -- | 
| 3 | 67% | 3% | 4% | 6 | 1 Week | 3 | 0% | -- | -- | -- | 
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                              InsiderInsights.com Sales Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 2 | 0% | 211% | 211% | 12 | 1 Year | 2 | 0% | -- | -- | -- | 
| 2 | 0% | 146% | 146% | 22 | 9 Month | 2 | 0% | -- | -- | -- | 
| 2 | 0% | 89% | 89% | 36 | 6 Month | 2 | 0% | -- | -- | -- | 
| 2 | 0% | 49% | 49% | 14 | 3 Month | 2 | 0% | -- | -- | -- | 
| 2 | 0% | 24% | 24% | 4 | 1 Month | 2 | 0% | -- | -- | -- | 
| 2 | 50% | 4% | 4% | 11 | 1 Week | 2 | 0% | -- | -- | -- | 
| Scorecards Updated 10/31/2025 10:09 AM EST | Latest Transaction Date: | 6/24/2013 | 
| Average days between Transaction and Entered Dates: | 2 | 
| 
                              InsiderInsights.com Purchase Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Purchases
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| -- | -- | -- | -- | -- | 1 Year | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 9 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 6 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 3 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Month | -- | -- | -- | -- | -- | 
| -- | -- | -- | -- | -- | 1 Week | -- | -- | -- | -- | -- | 
| 
                              InsiderInsights.com Sales Scorecard
                             | 
|  |  | 
                              Transaction Date
                             | 
| Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | Time From Sales
 | Nq | Hit Rate
 | Mean Return
 | Median Return
 | Range of Returns
 | 
| 5 | 100% | -77% | -80% | 6 | 1 Year | 5 | 100% | -77% | -78% | 0 | 
| 5 | 100% | -61% | -49% | 31 | 9 Month | 5 | 100% | -58% | -43% | 38 | 
| 5 | 100% | -47% | -32% | 38 | 6 Month | 5 | 100% | -45% | -31% | 37 | 
| 5 | 100% | -29% | -32% | 9 | 3 Month | 5 | 100% | -26% | -26% | 1 | 
| 5 | 60% | -2% | -13% | 27 | 1 Month | 5 | 60% | -0% | -7% | 16 | 
| 5 | 60% | -0% | -2% | 5 | 1 Week | 5 | 40% | -2% | 3% | 12 | 
| Scorecards Updated 12/26/2017 09:34 AM EST | Latest Transaction Date: | 2/25/2009 | 
| Average days between Transaction and Entered Dates: | 4 |