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 B  AB  JB*  OB  OE*  OE
 S  AS  JS*  OS  OS*  3
 JB
 JS
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Detailed Insider History for:
SPYRE THERAPEUTICS INC: SYRE
Price: 6/19/26 52-Wk
High		 52-Wk
Low		 Mkt Cap (mm) Shrs Out (mm) 3-Mth Ave
Vol (m)		 Ind. Yield Short Int
% Float		 Inst. Owned Insider Owned
$88.34 $90.99 $14.00 $7,672 87 1,212 0.0% 15.6% 97.79% 5.88%
Exch Sector Industry Sub-Industry
NasdaqGS Manufacturing Chemicals And Allied Products Pharmaceutical Preparations
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#
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Insider Statistics
T N H M S
Filer Name
Insider Title
Trans Type
Dollar Value
Shares Traded
Trans Date From
Trans Date To
Trans Price From
Trans Price To
Total Holdings
Delta % Owned
Owned
Other Info
Input Date
1
    
 
FAIRMOUNT FUNDS MANAGEMENT LLC
DIR
JS
$399,658,656
4,684,781
---
6/23/26
---
$85.31
---
All
I
---
6/23/26 - 9:56:26 pm
2
    
 
FAIRMOUNT FUNDS MANAGEMENT LLC
DIR
JB
---
666,680
---
6/23/26
---
---
4,684,781
16.6
I
---
6/23/26 - 9:56:26 pm
3
1m
1
100%
-2%
3
HENDERSON MICHAEL THOMAS
DIR
AS
$2,000,000
20,000
---
6/22/26
---
$100.00
68,606
-22.6
D
10b
6/23/26 - 9:32:23 pm
4
    
 
SLOAN SHELDON
O
OS
$624,975
8,333
---
6/3/26
---
$75.00
---
All
D
10b
6/3/26 - 9:32:02 pm
5
    
 
SLOAN SHELDON
O
OE
$228,824
8,333
---
6/3/26
---
$27.46
8,333
New
D
10b
6/3/26 - 9:32:02 pm
6
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$1,056,486
15,000
---
6/1/26
$69.40
$71.38
597,540
-2.4
D
10b
6/3/26 - 9:31:11 pm
7
    
 
BURROWS SCOTT L
CFO
OS
$532,937
7,500
---
6/1/26
$69.75
$72.06
97,994
-7.1
D
R,10b
6/3/26 - 9:30:41 pm
8
    
 
BURROWS SCOTT L
CFO
OE
$108,750
7,500
---
6/1/26
---
$14.50
105,494
7.7
D
R,10b
6/3/26 - 9:30:41 pm
9
1m
1
100%
-2%
3
HENDERSON MICHAEL THOMAS
DIR
AS
$5,952,051
80,000
---
5/8/26
$72.57
$75.35
88,606
-47.4
D
10b
5/8/26 - 9:31:49 pm
10
    
 
BURROWS SCOTT L
CFO
OS
$892,125
12,500
---
5/1/26
---
$71.37
97,994
-11.3
D
R,10b
5/1/26 - 9:35:12 pm
11
    
 
BURROWS SCOTT L
CFO
OE
$181,250
12,500
---
5/1/26
---
$14.50
110,494
12.8
D
R,10b
5/1/26 - 9:35:12 pm
12
    
 
SLOAN SHELDON
O
OS
$5,600,701
78,333
---
5/1/26
$69.53
$75.37
---
All
D
10b
5/1/26 - 9:34:39 pm
13
    
 
SLOAN SHELDON
O
OE
$2,151,024
78,333
---
5/1/26
---
$27.46
78,333
New
D
10b
5/1/26 - 9:34:39 pm
14
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$1,070,507
15,000
---
5/1/26
$69.54
$74.96
612,540
-2.4
D
10b
5/1/26 - 9:34:11 pm
15
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$739,912
15,000
---
4/1/26
$49.20
$49.92
627,540
-2.3
D
10b
4/3/26 - 9:30:43 pm
16
    
 
SLOAN SHELDON
O
AS
$397,900
7,958
---
4/1/26
---
$50.00
---
All
D
10b
4/3/26 - 9:30:11 pm
17
    
 
SLOAN SHELDON
O
OE
$172,370
7,958
---
4/1/26
---
$21.66
7,958
New
D
10b
4/3/26 - 9:30:11 pm
18
    
 
BURROWS SCOTT L
CFO
AS
$370,076
7,500
---
4/1/26
$49.21
$49.98
97,994
-7.1
D
R,10b
4/3/26 - 9:29:36 pm
19
    
 
BURROWS SCOTT L
CFO
OE
$108,750
7,500
---
4/1/26
---
$14.50
105,494
7.7
D
R,10b
4/3/26 - 9:29:36 pm
20
    
 
BURROWS SCOTT L
CFO
OS
$101,620
2,500
---
3/3/26
$40.56
$41.66
97,994
-2.5
D
R,10b
3/3/26 - 9:32:31 pm
21
    
 
BURROWS SCOTT L
CFO
OE
$36,250
2,500
---
3/3/26
---
$14.50
100,494
2.6
D
R,10b
3/3/26 - 9:32:31 pm
22
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$632,866
15,000
---
3/2/26
$41.73
$42.49
642,540
-2.3
D
10b
3/3/26 - 9:31:30 pm
23
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$492,045
15,000
---
2/2/26
$31.82
$32.87
657,540
-2.2
D
10b
2/4/26 - 9:33:37 pm
24
    
 
HENDERSON MICHAEL THOMAS
DIR
JB
---
63,227
---
1/21/26
---
---
168,606
60.0
D
---
1/23/26 - 9:31:12 pm
25
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$460,134
15,000
---
1/2/26
$30.47
$32.39
671,907
-2.2
D
10b
1/6/26 - 9:36:32 pm
26
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$435,356
15,000
---
12/1/25
$28.73
$29.83
686,907
-2.1
D
10b
12/3/25 - 9:52:20 pm
27
6m
2
0%
174%
3
TURTLE CAMERON
CEO,DIR
AS
$1,049,778
45,000
---
11/3/25
$23.13
$23.66
701,907
-6.0
D
10b
11/5/25 - 9:15:05 pm
28
    
 
BURROWS SCOTT L
CFO
S
$299,639
18,428
---
9/2/25
---
$16.26
97,994
-15.8
D
R
9/3/25 - 6:53:19 pm
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